RESEARCH STUDIES
Over Three Decades of Progress in Transdermal Science
Since the introduction of the nicotine patch in 1991—one of the most widely adopted transdermal therapies—the power of skin-based delivery has been validated across science and society.
Its success proved what’s possible: effective, convenient, and sustained support without the need for pills.
At ODEA, we’ve taken this proven method and reimagined it for daily wellness.
Since 2010, transdermal technology has evolved beyond pharmaceuticals (e.g. nicotine, hormone, and pain relief patches) to include wellness and nutritional applications.
At ODEA™, we aim to harness this proven delivery system to develop high-quality wellness patches that support well-being through steady, skin-based nutrient release.
Our guiding principle: Use ingredients with clinical backing, formulated in skin-permeable forms, to deliver meaningful support, without the need for pills.
RESEARCH TIMELINE
Raising the Bar for Supplement Science
At ODEA, our R&D team actively explores independent, peer-reviewed research to deepen our understanding of transdermal nutrient delivery.
We stay ahead of the curve: continuously integrating new scientific insights to ensure each patch is formulated with purpose and precision.
Rooted in dermatological science and guided by the principles of passive diffusion, our work is designed to work with your body, not against it.
Every patch we develop reflects our commitment to research, innovation, and well-being that lasts.
01 - CLINICAL INSIGHT
What We Know So Far
While peer-reviewed, placebo-controlled trials are still emerging in this field, early findings are helping define what’s possible, and where limitations exist.
For example:
- A pilot study in bariatric patients suggested that some multivitamin patches underperformed compared to oral supplements in terms of B12 and vitamin D serum levels.
- In contrast, melatonin shows strong promise: a placebo-controlled trial using a 2.1 mg transdermal patch found 53% fewer sleep disruptions in daytime sleepers.
- Fat-soluble vitamins like D and E, when properly formulated, have shown early potential for successful transdermal delivery.
Why This Matters
Not all nutrients are suited for skin-based absorption. Our focus is on those with transdermal viability, such as melatonin, caffeine, vitamin D, and certain antioxidants.
While continuously refining formulations to maximize comfort and bioavailability.
02 — IN VITRO SKIN PERMEABILITY STUDY
Testing Absorption
in the Lab
Using validated human skin models, research teams tested which compounds could passively diffuse through the stratum corneum.
Findings align with well-established dermatological principles: compounds under 500 Daltons and lipophilic in nature are more likely to absorb through the skin.
- Vitamin D (384 Da), caffeine (194 Da), and melatonin (232 Da) all fall within this threshold.
- Natural permeation enhancers increased absorption by 30–40%, depending on the molecule and formulation.
Why This Matters
Formulation is everything.
By pairing transdermally compatible nutrients with plant-based permeation enhancers and controlled-release systems, our patches are designed for optimal delivery and ease of use.
03 — CONSUMER FEEDBACK STUDY
Real-World Results
from Real People
In a 12-week internal survey of 75 wellness-conscious adults (ages 28–54), participants self-reported the following:
- 81% noticed more consistent daily energy
- 72% reported better sleep within 3 weeks
- 66% felt better able to manage stress
Why This Matters
While not a clinical trial, these insights offer a valuable look into how people actually use and perceive transdermal patches in their daily lives.
We believe in transparency:
these results are based on self-reported experiences, and individual results may vary.
Scientific Rigor
& Transparancy
At ODEA™, we’re committed to advancing the science of transdermal delivery, so your body gets what it needs, when it needs it.
But our mission goes deeper. We believe true wellness is holistic. It’s how you sleep, how you recover, how you feel in your skin. That’s why every patch is thoughtfully crafted to support your full self: mind, body, and rhythm.
We’re committed to progress you can feel.
Through ongoing research, we’re refining what works—and rethinking what doesn’t—so every patch delivers even greater impact.
Note: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Discover our carefully crafted transdermal wellness patches, with curated natural ingredients.
A single patch. A lifetime of better days.
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REFERENCES
Bos, J. D., & Meinardi, M. M. (2000). The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Experimental Dermatology, 9 (3), 165–169.
Prausnitz, M. R., Mitragotri, S., & Langer, R. (2004). Current status and future potential of transdermal drug delivery. Nature Reviews Drug Discovery, 3, 115–124.
pmc.ncbi.nlm.nih.gov, pmc.ncbi.nlm.nih.gov.
Grammatikopoulou, M. G., et al. (2021).
Peeking into the future: Transdermal patches for the delivery of micronutrient supplements.
Metabolism Open, 11, 100109.
pmc.ncbi.nlm.nih.gov, pmc.ncbi.nlm.nih.gov.
Saurabh, S., Gao, Y., Maduka, S., et al. (2019). Is transdermal multivitamin patch effective in gastric bypass patients? Obesity Surgery, 29 (12), 3818–3823.
Aeschbach, D., Sher, L., Kripke, D. F., et al. (2009). Use of transdermal melatonin delivery to improve sleep maintenance during daytime.
Clinical Pharmacology & Therapeutics, 86 (4), 378–382. researchgate.net
Hamman, J. H., et al. (2011). Transdermal drug delivery enhancement by compounds of natural origin.
International Journal of Molecular Sciences, 12 (4), 784–795. pmc.ncbi.nlm.nih.gov